Sample size estimation for balanced randomised control trials

This post presents an R function to implement the sample size estimation presented in Twisk (2013) for continuous outcomes.

Formula 11.1 is used when the researcher wants to compare two groups at one single point in time (e.g., placebo versus treatment at post-intervention), whereas Formula 11.3 is used when there is more than one follow-up measurement and the researcher is interested in comparing the two groups based on the average in the outcome variable over the total follow-up period.

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